No, the Seresto collar is not a natural product. The Seresto collar is made of synthetic materials, including an evergreen oil-based pesticide that slowly releases into the animal’s oil glands beneath the fur, more commonly known as permethrin. This pesticide has been found to be toxic to animals when used in concentrated form and is regulated by the Environmental Protection Agency (EPA). Additionally, the Seresto collar contains another active ingredient called imidacloprid which has been linked to neurotoxic effects in some pets. While both compounds are FDA approved and considered safe for use on animals, they may not be natural products.